International Science Symposium
Mechanisms of Anesthesia
Moderator Emery N. Brown, MD, PhD
What is General Anesthesia?
The objective of the science symposium was to
develop a characterization of the states of the brain
under general anesthesia in terms of the action of
anesthetics at specific receptors in specific neural
circuits. We know a lot about the molecular targets
of drugs and the clinical behavioral states after anesthesia,
but we are missing the link between those two elements.
Cortical Feedback and General Anesthesia. George A. Mashour, MD, PhD discussed cortical feedback and
general anesthesia, the gap in the study of
consciousness and anesthesia, and described the
basic principles of consciousness.
Neurophysiological Correlates of Unconsciousness
Under General Anesthesia. Patrick L. Purdon, PhD
discussed how to recognize electroencephalographic
patterns observed during general anesthesia, and
understand the mechanisms underlying these patterns.
Active Reanimation from General Anesthesia. Ken Solt, MD reviewed the arousal pathways in the brain and how activation of arousal pathways can be used to induce
active reanimation from general anesthesia.
Anesthetic Amnesia: Insights from Human Subject
Research. Kane O. Pryor, MD discussed the neural
circuits responsible for memory formation and possible mechanisms of anesthetic induced amnesia.
See the link below for more information on mechanisms
of anesthesia: http://www.nature.com/npp/journal/v28/n1s/full/1300142a.html